Understanding PDRN: Mechanism of Action in Skin Regeneration

A comprehensive review of how polydeoxyribonucleotide promotes tissue repair through adenosine A2A receptor activation and downstream signaling pathways.

Polydeoxyribonucleotide (PDRN) exerts its regenerative effects primarily through activation of the adenosine A2A receptor, triggering a cascade of cellular responses including increased VEGF production, enhanced fibroblast proliferation, and accelerated extracellular matrix remodeling. This article reviews the current scientific understanding of PDRN's mechanism of action in skin regeneration, drawing on clinical studies and preclinical research.